Ok, so I don't believe in first-strike, and so I respond badly to being nuked... And by that I mean I make sure you get nuked to the stone age.
So far only 1 person has ever fended me off (Yo mongus!)
The trick? Well you build lots of nuke silos, and then while those are building missiles you go and build EMP silos in a FOB that has them within range of the edge of the anti-nuke coverage zone you are gunning for.
They will either a) overwhelm their ability to fire anti's fast enough, or b) will simply eat up their stock.
The counter to this is to spam antinuke units/silos- but nobody really does this it seems.
So if you are playing me I have 2 bits of advice:
1) Never, ever, think you have a viable first-strike option.
2) If you make the mistake, divert most of your resources to anti-nuke until you have no problem stopping my salvos, and could handle twice that.
BTW since they changed the reload rate on anti-nukes, it has seriously nerfed nukes, which is fine by me.